Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with schistosomes.

doi:10.1084/jem.20090383

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Article

Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with schistosomes.

The Journal of experimental medicine - 26 Oct 2009

Dessein Alain, Chevillard Christophe, Arnaud Violaine, Hou Xunya, Hamdoun Anas Ahmed, Dessein Helia, He Hongbin, Abdelmaboud Suzan A, Luo Xinsong, Li Jun, Varoquaux Arthur, Mergani Adil, Abdelwahed Mohammed, Zhou Jie, Monis Ahmed, Pitta Maira G R, Gasmelseed Nagla, Cabantous Sandrine, Zhao Yaqing, Prata Aluizio, Brandt Carlos, Elwali Nasr Eldin, Argiro Laurent, Li Yuesheng

Abstract excerpt

Abnormal fibrosis occurs during chronic hepatic inflammations and is the principal cause of death in hepatitis C virus and schistosome infections. Hepatic fibrosis (HF) may develop either slowly or rapidly in schistosome-infected subjects. This depends, in part, on a major genetic control exerted by genes of chromosome 6q23. A gene (connective tissue growth factor [CTGF]) is located in that region that encodes a...

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PMID: 19822645
DOI: 10.1084/jem.20090383
PMCID: PMC2768853

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