Article
Polymorphisms of the renin-angiotensin system and the severity of fibrosis in chronic hepatitis C virus infection.
Journal of viral hepatitis - 1 Sept 2005
Forrest E H, Thorburn D, Spence E, Oien K A, Inglis G, Smith C-A, McCruden E A B, Fox R, Mills P R
Abstract excerpt
SUMMARY: Patients with chronic hepatitis C virus (HCV) infection vary in their rates of fibrosis progression. The renin-angiotensin system (RAS) regulates fibrosis. Polymorphisms in the genes of the RAS may contribute to the outcome of renal and cardiovascular disease. We studied four RAS gene polymorphisms in 195 patients with chronic HCV infection. Patients were grouped by Ishak stage of fibrosis on liver...
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