Article
Effects of common haplotypes of the ileal sodium dependent bile acid transporter gene on the development of sporadic and familial colorectal cancer: a case control study.
BMC medical genetics - 21 Jul 2008
Grünhage Frank, Jungck Matthias, Lamberti Christoph, Keppeler Hildegard, Becker Ursula, Schulte-Witte Hildegard, Plassmann Dominik, Friedrichs Nicolaus, Buettner Reinhard, Aretz Stefan, Sauerbruch Tilman, Lammert Frank
Abstract excerpt
BACKGROUND: The genetics of sporadic and non-syndromic familial colorectal cancer (CRC) is not well defined. However, genetic factors that promote the development of precursor lesions, i.e. adenomas, might also predispose to CRC. Recently, an association of colorectal adenoma with two variants (c.507C>T;p.L169L and c.511G>T;p.A171S) of the ileal sodium dependent bile acid transporter gene (SLC10A2) has been...
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