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Article

Molecular dynamics simulations of GABA binding to the GABAC receptor: the role of Arg104.

Biophysical journal - 1 Nov 2008

Melis Claudio, Lummis Sarah C R, Molteni Carla

Abstract excerpt

GABA is the major inhibitory neurotransmitter in the nervous system and acts at a variety of receptors including GABAC receptors, which are a subclass of GABAA receptors. Here we have used molecular dynamics simulations of GABA docked into the extracellular domain of the GABAC receptor to explain the molecular interactions of the neurotransmitter with the residues that contribute to the binding site; in...

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Identifiers

PMID: 18641081
DOI: 10.1529/biophysj.107.127589
PMCID: PMC2567930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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