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Article

Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor

18 Jul 2008

Abstract excerpt

We previously reported an epidemiologically linked HIV-1 infected patient cohort in which a long-term non-progressor (LTNP) infected two recipients who then exhibited normal disease progression. Expression of patient-derived vpr sequences from each of the three cohort members in mammalian cells tagged with GFP revealed a significant reduction in Vpr nuclear import and virion incorporation uniquely from the LTNP,...

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PMID: 18638397
DOI: 10.1186/1742-4690-5-67

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