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Article

Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2008

Zhou Zongmin, Sayed Nazish, Pyriochou Anastasia, Roussos Charis, Fulton David, Beuve Annie, Papapetropoulos Andreas

Abstract excerpt

OBJECTIVE: Binding of nitric oxide (NO) to soluble guanylyl cyclase (sGC) leads to increased cGMP synthesis that activates cGMP-dependent protein kinase (PKG). Herein, we tested whether sGC activity is regulated by PKG. METHODS AND RESULTS: Overexpression of a constitutively active form of PKG (DeltaPKG) stimulated (32)P incorporation into the alpha1 subunit. Serine to alanine mutation of putative sites revealed...

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Identifiers

PMID: 18635821
DOI: 10.1161/ATVBAHA.108.165043
PMCID: PMC2763424

Genes

VASP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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