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Article

Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation.

PloS one - 5 Nov 2010

Lessi Francesca, Beggs Andrew, de Palo Mariagrazia, Anti Marcello, Macarone Palmieri Raffaele, Francesconi Simona, Gomes Vito, Bevilacqua Generoso, Tomlinson Ian, Segditsas Stefania

Abstract excerpt

BACKGROUND: We have previously shown that serum/glucocorticoid regulated kinase 1 (SGK1) is down-regulated in colorectal cancers (CRC) with respect to normal tissue. As hyper-methylation of promoter regions is a well-known mechanism of gene silencing in cancer, we tested whether the SGK1 promoter...

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Identifiers

PMID: 21079778
DOI: 10.1371/journal.pone.0013840
PMCID: PMC2974649

Genes

SGK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21079778-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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