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Article

Structural comparisons of class I phosphoinositide 3-kinases.

Nature reviews. Cancer - 1 Sept 2008

Amzel L Mario, Huang Chuan-Hsiang, Mandelker Diana, Lengauer Christoph, Gabelli Sandra B, Vogelstein Bert

Abstract excerpt

Class I phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate cell growth. One of these kinases, PI3Kalpha, is frequently mutated in diverse tumour types. The recently determined structure of PI3Kalpha reveals features that distinguish this enzyme from related lipid kinases. In addition, wild-type PI3Kgamma differs from PI3Kalpha by a substitution identical to a PI3Kalpha oncogenic mutant...

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Identifiers

PMID: 18633356
DOI: 10.1038/nrc2443
PMCID: PMC2847604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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