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Article

Ras mutational status is a biomarker for resistance to EGFR inhibitors in colorectal carcinoma.

Anticancer research - 1 Nov 2010

Dempke Wolfram C M, Heinemann Volker

Abstract excerpt

The epidermal growth factor receptor (EGFR) has been validated as a therapeutic target in several human tumours, including colorectal cancer (CRC). Although EGFR expression is used for patient selection, clinical experience shows that levels of EGFR expression (measured by immunohistochemistry) do not predict clinical benefit. Ras mutations in codons 12, 13 and 61 (found in 40-45% of CRC cases) result in...

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PMID: 21115922

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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