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Article

[Identification of K-RAS mutations in colorectal cancer patients in Israel].

Harefuah - 1 May 2011

Segal Gadi, Liebermann Nicky, Klang Shmuel, Siegelmann-Daniel Nava, Beit-Or Anat, Klien Baruch, Shoushan-Gutman Lior

Abstract excerpt

BACKGROUND: Activating mutations of the oncogene K-RAS are a common finding within cells of malignant, sporadic colorectal cancer. The existence of such mutations endows the tumor with proliferation potential which is independent of external stimuli by growth factors such as the epidermal growth factor of upstream receptor (EGFR]. Hence, anticancer, novel biologic drugs, aimed at inhibiting the EGFR, such as...

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PMID: 21678640

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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