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Article

Supraphysiological androgen levels induce cellular senescence in human prostate cancer cells through the Src-Akt pathway

12 Sept 2014

Abstract excerpt

BACKGROUND: Prostate cancer (PCa) is the second leading cause of cancer mortality of men in Western countries. The androgen receptor (AR) and AR-agonists (androgens) are required for the development and progression of the normal prostate as well as PCa. However, it is discussed that in addition to their tumor promoting activity, androgens may also exhibit tumor suppressive effects. A biphasic growth response to...

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PMID: 25216853
DOI: 10.1186/1476-4598-13-214

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