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Article

Targeting IKKε in Androgen-Independent Prostate Cancer Causes Phenotypic Senescence and Genomic Instability.

Molecular cancer therapeutics - 1 Mar 2022

Gilbert Sophie, Péant Benjamin, Malaquin Nicolas, Tu Véronique, Fleury Hubert, Leclerc-Desaulniers Kim, Rodier Francis, Mes-Masson Anne-Marie, Saad Fred

Abstract excerpt

Advanced prostate cancer will often progress to a lethal, castration-resistant state. We previously demonstrated that IKKε expression correlated with the aggressiveness of prostate cancer disease. Here, we address the potential of IKKε as a therapeutic target in prostate cancer. We examined cell fate decisions (proliferation, cell death, and senescence) in IKKε-depleted PC-3 cells, which exhibited delayed cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34965959
DOI: 10.1158/1535-7163.MCT-21-0519
PMCID: PMC9377745

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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