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Article

Evidence of oncogene-induced senescence in thyroid carcinogenesis

21 Sept 2011

Abstract excerpt

Oncogene-induced senescence (OIS) is a growth arrest triggered by the enforced expression of cancer-promoting genes and acts as a barrier against malignant transformation in vivo. In this study, by a combination of in vitro and in vivo approaches, we investigate the role of OIS in tumours originating from the thyroid epithelium. We found that expression of different thyroid tumour-associated oncogenes in primary...

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PMID: 21937739
DOI: 10.1530/erc-11-0240

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