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Article

Persistence of senescent prostate cancer cells following prolonged neoadjuvant androgen deprivation therapy.

PloS one - 1 Jan 2017

Blute Michael L, Damaschke Nathan, Wagner Jennifer, Yang Bing, Gleave Martin, Fazli Ladan, Shi Fangfang, Abel E Jason, Downs Tracy M, Huang Wei, Jarrard David F

Abstract excerpt

PURPOSE: Androgen deprivation therapy (ADT) commonly leads to incomplete cell death and the fate of persistent cells involves, in part, a senescent phenotype. Senescence is terminal growth arrest in response to cell stress that is characterized by increased lysosomal-β-galactosidase (GLB1) the origin of senescence associated-β-gal activity (SA-β-gal). In the current study senescence is examined in vivo after ADT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28234906
DOI: 10.1371/journal.pone.0172048
PMCID: PMC5325224

Genes

GLB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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