Article
Attenuation of left ventricular dysfunction by an ACE inhibitor after myocardial infarction in a kininogen-deficient rat model.
Biological chemistry - 1 Jun 2008
Koch Matthias, Bonaventura Klaus, Spillmann Frank, Dendorfer Andreas, Schultheiss Heinz-Peter, Tschöpe Carsten
Abstract excerpt
Bradykinin (BK) coronary outflow and left ventricular (LV) performance of kininogen-deficient Brown Norway Katholiek (BNK) rats and Brown Norway Hannover (BNH) controls were investigated. We analyzed whether the angiotensin-converting enzyme (ACE) inhibitor ramipril is able to attenuate LV dysfunction after induction of myocardial infarction (MI) in this animal model. Ex vivo, the basal BK content in the coronary...
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