Article
Recombination and selection can remove blaTEM alleles from bacterial populations.
Antimicrobial agents and chemotherapy - 1 Sept 2008
Mroczkowska Joanna E, Barlow Miriam
Abstract excerpt
We passaged cells expressing TEM-1 and TEM-12 from a single plasmid through either ampicillin or ceftazidime. We found that the combined effects of recombination and selection removed the bla(TEM-1) allele from the bacterial population when it was passaged through ceftazidime or the bla(TEM-12) allele when cultures were passaged through ampicillin.
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