Article
Functional variant in the (alpha)2B adrenoceptor gene, a positional candidate on chromosome 2, associates with hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Mar 2004
Von Wowern Fredrik, Bengtsson Kristina, Lindblad Ulf, Råstam Lennart, Melander Olle
Abstract excerpt
In a genome-wide scan in Scandinavians, we found suggestive linkage between early-onset primary hypertension and a region on chromosome 2. The alpha(2B)-adrenoceptor gene, a candidate gene within this region, harbors a functional insertion/deletion (I/D) polymorphism of three glutamate residues. The aim of this study was to investigate if the DD genotype is associated with hypertension in Swedes. We performed an...
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