Article
Somatic PIK3CA mutations as a driver of sporadic venous malformations.
Science translational medicine - 30 Mar 2016
Castel Pau, Carmona F Javier, Grego-Bessa Joaquim, Berger Michael F, Viale Agnès, Anderson Kathryn V, Bague Silvia, Scaltriti Maurizio, Antonescu Cristina R, Baselga Eulàlia, Baselga José
Abstract excerpt
Venous malformations (VM) are vascular malformations characterized by enlarged and distorted blood vessel channels. VM grow over time and cause substantial morbidity because of disfigurement, bleeding, and pain, representing a clinical challenge in the absence of effective treatments (Nguyenet al, 2014; Uebelhoeret al, 2012). Somatic mutations may act as drivers of these lesions, as suggested by the...
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