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Article

Determination and Stability of Gonadal Sex

2 Jan 2010

Abstract excerpt

The discovery that the SRY gene induces male sex in humans and other mammals led to speculation about a possible equivalent for female sex. But females are proving to be more complicated. Several master genes appear to be autonomously involved, and female sex determination seems to remain relatively labile. Partial loss of function of the transcription factor FOXL2 leads to premature ovarian failure in women; and...

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Identifiers

PMID: 19875493
DOI: 10.2164/jandrol.109.008201

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