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Article

Loss of Wnt4 and Foxl2 leads to female-to-male sex reversal extending to germ cells

29 Aug 2007

Abstract excerpt

The discovery that the SRY gene induces male sex in humans and other mammals led to speculation about a possible equivalent for female sex. However, only partial effects have been reported for candidate genes experimentally tested so far. Here we demonstrate that inactivation of two ovarian somatic factors, Wnt4 and Foxl2, produces testis differentiation in XX mice, resulting in the formation of testis tubules...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 17728319
DOI: 10.1093/hmg/ddm235

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