Article
Genome-wide genetic characterization of an atypical meningioma by single-nucleotide polymorphism array-based mapping and classical cytogenetics.
Cancer genetics and cytogenetics - 15 Jul 2008
Krupp Wolfgang, Holland Heidrun, Koschny Ronald, Bauer Manfred, Schober Ralf, Kirsten Holger, Livrea Michela, Meixensberger Jürgen, Ahnert Peter
Abstract excerpt
Most meningiomas, accounting for about 20% of intracranial tumors, can be cured by surgical removal. Yet, 8-22% of these tumors are classified as atypical or anaplastic (WHO grade II or III, respectively) presenting with a more aggressive behavior and a high relapse rate. We analyzed genomic alterations of an atypical meningioma using high-density single nucleotide polymorphism arrays (SNP-A) karyotyping combined...
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