Article
Detection of novel genomic aberrations in anaplastic astrocytomas by GTG-banding, SKY, locus-specific FISH, and high density SNP-array.
Pathology, research and practice - 15 Jun 2012
Holland Heidrun, Ahnert Peter, Koschny Ronald, Kirsten Holger, Bauer Manfred, Schober Ralf, Meixensberger Jürgen, Fritzsch Dominik, Krupp Wolfgang
Abstract excerpt
Astrocytomas represent the largest and most common subgroup of brain tumors. Anaplastic astrocytoma (WHO grade III) may arise from low-grade diffuse astrocytoma (WHO grade II) or as primary tumors without any precursor lesion. Comprehensive analyses of anaplastic astrocytomas combining both cytogenetic and molecular cytogenetic techniques are rare. Therefore, we analyzed genomic alterations of five anaplastic...
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