Article
Plasminogen activator inhibitor-1 4G/5G gene polymorphism and primary open-angle glaucoma.
Molecular vision - 4 Jul 2008
Mossböck Georg, Weger Martin, Faschinger Christoph, Schmut Otto, Renner Wilfried
Abstract excerpt
PURPOSE: Alterations of the plasmin system have been suggested to participate in the multifactorial pathogenesis of primary open-angle glaucoma (POAG). The main physiological inhibitor of the plasmin system is plasminogen activator inhibitor-1 (PAI-1), which leads to decreased degradation of extracellular material. Interestingly, elevated PAI-1 levels in the aqueous humor of patients with POAG have been reported....
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