Article
Single-nucleotide polymorphisms in human beta-defensin-1 gene in Mozambican HIV-1-infected women and correlation with virologic parameters.
AIDS (London, England) - 31 Jul 2008
Baroncelli Silvia, Ricci Elisabetta, Andreotti Mauro, Guidotti Giovanni, Germano Paola, Marazzi Maria Cristina, Vella Stefano, Palombi Leonardo, De Rossi Anita, Giuliano Marina
Abstract excerpt
We analyzed single nucleotide polymorphisms in the 5'-untranslated region (-44C/G and -52G/A) of the beta-defensin-1 gene in 78 Mozambican HIV-1-infected mothers. We observed significantly lower levels of HIV-1 RNA in breast milk, but not in plasma, in women with the -52GG genotype versus women with the -52GA and -52AA genotypes, supporting the hypothesis that different expression of beta-defensins could have an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.