Article
The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.
PloS one - 9 Jul 2008
Ahmad Ferhaan, Banerjee Sanjay K, Lage Michele L, Huang Xueyin N, Smith Stephen H, Saba Samir, Rager Jennifer, Conner David A, Janczewski Andrzej M, Tobita Kimimasa, Tinney Joseph P, Moskowitz Ivan P, Perez-Atayde Antonio R, Keller Bradley B, Mathier Michael A, Shroff Sanjeev G, Seidman Christine E, Seidman J G
Abstract excerpt
BACKGROUND: Hypertrophic (HCM) and dilated (DCM) cardiomyopathies result from sarcomeric protein mutations, including cardiac troponin T (cTnT, TNNT2). We determined whether TNNT2 mutations cause cardiomyopathies by altering cTnT function or quantity; whether the severity of DCM is related to the ratio of mutant to wildtype cTnT; whether Ca(2+) desensitization occurs in DCM; and whether absence of cTnT impairs...
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