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Article

Different functional properties of troponin T mutants that cause dilated cardiomyopathy.

The Journal of biological chemistry - 24 Oct 2003

Venkatraman Gayathri, Harada Keita, Gomes Aldrin V, Kerrick W Glenn L, Potter James D

Abstract excerpt

The effects of Troponin T (TnT) mutants R141W and DeltaK210, the only two currently known mutations in TnT that cause dilated cardiomyopathy(DCM) independent of familial hypertrophic cardiomyopathy (FHC), and TnT-K273E, a mutation that leads to a progression from FHC to DCM, were investigated. Studies on the Ca2+ sensitivity of force development in porcine cardiac fibers demonstrated that TnT-DeltaK210 caused a...

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Identifiers

PMID: 12923187
DOI: 10.1074/jbc.M302148200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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