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Article

Cardiac troponin T is essential in sarcomere assembly and cardiac contractility.

Nature genetics - 1 May 2002

Sehnert Amy J, Huq Anja, Weinstein Brant M, Walker Charline, Fishman Mark, Stainier Didier Y R

Abstract excerpt

Mutations of the gene (TNNT2) encoding the thin-filament contractile protein cardiac troponin T are responsible for 15% of all cases of familial hypertrophic cardiomyopathy, the leading cause of sudden death in young athletes. Mutant proteins are thought to act through a dominant-negative mode that impairs function of heart muscle. TNNT2 mutations can also lead to dilated cardiomyopathy, a leading cause of heart...

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Source

Identifiers

PMID: 11967535
DOI: 10.1038/ng875

Genes

TNNT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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