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Article

2'-5' oligoadenylate synthetase shares active site architecture with the archaeal CCA-adding enzyme.

Cellular and molecular life sciences : CMLS - 1 Aug 2008

Torralba S, Sojat J, Hartmann R

Abstract excerpt

The 2'-5' oligoadenylate synthetases (OAS) are interferon-induced antiviral enzymes that recognise virally produced dsRNA and initiate an RNA destabilisation within the infected cell. We compared the structure of OAS to that of poly adenosine polymerase (PAP) and the class I CCA-adding enzyme from Archeoglobus fulgidus (AfCCA). This comparison revealed a strong structural homology between the three enzyme...

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Identifiers

PMID: 18604630
DOI: 10.1007/s00018-008-8164-5
PMCID: PMC11131617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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