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Article

A-to-I editing of Malacoherpesviridae RNAs supports the antiviral role of ADAR1 in mollusks

23 Jul 2019

Abstract excerpt

BACKGROUND: Adenosine deaminase enzymes of the ADAR family are conserved in metazoans. They convert adenine into inosine in dsRNAs and thus alter both structural properties and the coding potential of their substrates. Acting on exogenous dsRNAs, ADAR1 exerts a pro- or anti-viral role in vertebrates and Drosophila. RESULTS: We traced 4 ADAR homologs in 14 lophotrochozoan genomes and we classified them into ADAD,...

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PMID: 31337330
DOI: 10.1186/s12862-019-1472-6

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