Article
Nucleophosmin mutations in de novo acute myeloid leukemia: the age-dependent incidences and the stability during disease evolution.
Cancer research - 15 Mar 2006
Chou Wen-Chien, Tang Jih-Luh, Lin Liang-In, Yao Ming, Tsay Woei, Chen Chien-Yuan, Wu Shang-Ju, Huang Chi-Fei, Chiou Rong-Jing, Tseng Mei-Hsuan, Lin Dong-Tsamn, Lin Kai-Hsin, Chen Yao-Chang, Tien Hwei-Fang
Abstract excerpt
Nucleophosmin (NPM) mutations have been found in a significant proportion of adults with de novo acute myeloid leukemia (AML), especially in those of a normal karyotype. These results provide a basis for studies of the pathogenesis in this specific subgroup of AML. In this study, NPM mutations were analyzed in 173 Chinese patients of de novo AML, including adults and children. We found that NPM mutations were...
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