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Article

Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro.

The Journal of pathology - 1 Aug 2013

Wang Jia, Zhao Jingmin, Chu Eagle S H, Mok Myth T S, Go Minnie Y Y, Man Kwan, Heuchel Rainer, Lan Hui Yao, Chang Zhijie, Sung Joseph J Y, Yu Jun

Abstract excerpt

Smad7 is a principal inhibitor of the TGFβ-Smad signalling pathway. We have investigated the functional significance of Smad7 in hepatocellular carcinoma (HCC). Smad7 knockout (KO) and wild-type (WT) mice were injected with diethylnitrosamine (DEN) to induce HCC. The effects of Smad7 on cellular features were examined in HCC cells, using a Smad7 over-expression or deletion approach. Signalling pathway components...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23625826
DOI: 10.1002/path.4206

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TAB2

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