Article
The ACAA-insertion/deletion polymorphism at the 3' UTR of the IGF-II receptor gene is associated with type 2 diabetes and surrogate markers of insulin resistance.
European journal of endocrinology - 1 Aug 2006
Villuendas Gemma, Botella-Carretero José I, López-Bermejo Abel, Gubern Carme, Ricart Wifredo, Fernández-Real José Manuel, San Millán José L, Escobar-Morreale Héctor F
Abstract excerpt
OBJECTIVE: The IGF-II receptor gene (IGFIIR) is located at chromosome 6q26, a region that harbors a genetic marker linked to insulin-resistant traits in Mexican-Americans. In the present study conducted in Spaniards, we tested a common polymorphism in IGFIIR for association with type 2 diabetes and insulin-resistant traits. DESIGN: Case-control association study. METHODS: One hundred and forty-five type 2...
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