Biased tests of association: comparisons of allele frequencies when departing from Hardy-Weinberg proportions.

Abstract excerpt

Association studies of genetic markers or candidate genes with disease are often conducted using the traditional case-control design. Cases and controls are sampled from genetically unrelated subjects, and allele frequencies compared between cases and controls using Pearson's chi-square statistic. An assumption of this analysis method is that the two alleles within each subject are statistically independent, at...

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