Article
Functional genomics of PycR, a LysR family transcriptional regulator essential for maintenance of Pseudomonas aeruginosa in the rat lung.
Microbiology (Reading, England) - 1 Jul 2008
Kukavica-Ibrulj Irena, Sanschagrin François, Peterson Ashley, Whiteley Marvin, Boyle Brian, MacKay John, Levesque Roger C
Abstract excerpt
The human opportunistic pathogen Pseudomonas aeruginosa is the major cause of morbidity and mortality of cystic fibrosis patients and is responsible for a variety of infections in compromised hosts. Using PCR-based signature-tagged mutagenesis, we identified a P. aeruginosa STM5437 mutant with an insertion into the PA5437 gene (called pycR for putative pyruvate carboxylase regulator). PycR inactivation results in...
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