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Article

Beyond odds ratios--communicating disease risk based on genetic profiles.

Nature reviews. Genetics - 1 Apr 2009

Kraft Peter, Wacholder Sholom, Cornelis Marilyn C, Hu Frank B, Hayes Richard B, Thomas Gilles, Hoover Robert, Hunter David J, Chanock Stephen

Abstract excerpt

The brisk discovery of novel inherited disease markers by genome-wide association (GWA) studies has raised expectations for predicting disease risk by analysing multiple common alleles. However, the statistics used during the discovery phase of research (such as odds ratios or p values for association) are not the most appropriate measures for evaluating the predictive value of genetic profiles. We argue that...

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PMID: 19238176
DOI: 10.1038/nrg2516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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