Article
A point mutation in the proteolipid protein gene of the 'shaking pup' interrupts oligodendrocyte development.
Development (Cambridge, England) - 1 Oct 1990
Nadon N L, Duncan I D, Hudson L D
Abstract excerpt
The differentiation of the oligodendrocyte from its bipotential progenitor culminates in the production of the myelin-specific proteins and the elaboration of membrane processes that ensheath the axon. Mutations in proteolipid protein (PLP) and its alternatively spliced isoform DM-20, the major protein constituents of central nervous system myelin, are characterized by a significant reduction in the number of...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Central Nervous System
- Diffuse Cerebral Sclerosis of Schilder
- Disease Models, Animal
- Dogs
- Exons
- Mice
- Mice, Transgenic
- Molecular Sequence Data