Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A point mutation in the proteolipid protein gene of the 'shaking pup' interrupts oligodendrocyte development.

Development (Cambridge, England) - 1 Oct 1990

Nadon N L, Duncan I D, Hudson L D

Abstract excerpt

The differentiation of the oligodendrocyte from its bipotential progenitor culminates in the production of the myelin-specific proteins and the elaboration of membrane processes that ensheath the axon. Mutations in proteolipid protein (PLP) and its alternatively spliced isoform DM-20, the major protein constituents of central nervous system myelin, are characterized by a significant reduction in the number of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 1723945
DOI: 10.1242/dev.110.2.529

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A point mutation in the proteolipid protein gene of the 'shaking pup' interrupts oligodendrocyte development.PMID 1723945Read ↗

Intracellular transport of the DM-20 bearing shaking pup (shp) mutation and its possible phenotypic consequences.Semantic proximity Read ↗

Jimpy-4J mouse has a missense mutation in exon 2 of the Plp gene.Semantic proximity Read ↗

The evolution of lipophilin genes from invertebrates to tetrapods: DM-20 cannot replace proteolipid protein in CNS myelin.Semantic proximity Read ↗

Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice.Semantic proximity Read ↗

Current concepts of PLP and its role in the nervous system.Semantic proximity Read ↗

The pathobiology of myelin mutants reveal novel biological functions of the MBP and PLP genes.Semantic proximity Read ↗

Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene.Semantic proximity Read ↗

The proteolipid protein gene and myelin disorders in man and animal models.Semantic proximity Read ↗

The molecular genetics of myelination: an update.Semantic proximity Read ↗

Myelin mutants: model systems for the study of normal and abnormal myelination.Semantic proximity Read ↗

Genotype-phenotype correlation in inherited brain myelination defects due to proteolipid protein gene mutations. Clinical European Network on Brain Dysmyelinating Disease.Semantic proximity Read ↗

The early phenotype associated with the jimpy mutation of the proteolipid protein gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.