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Article

DOC2B acts as a calcium switch and enhances vesicle fusion.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Jul 2008

Friedrich Reut, Groffen Alexander J, Connell Emma, van Weering Jan R T, Gutman Orit, Henis Yoav I, Davletov Bazbek, Ashery Uri

Abstract excerpt

Calcium-dependent exocytosis is regulated by a vast number of proteins. DOC2B is a synaptic protein that translocates to the plasma membrane (PM) after small elevations in intracellular calcium concentration. The aim of this study was to investigate the role of DOC2B in calcium-triggered exocytosis. Using biochemical and biophysical measurements, we demonstrate that the C2A domain of DOC2B interacts directly with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18596155
DOI: 10.1523/JNEUROSCI.0538-08.2008
PMCID: PMC2673511

Genes

DOC2B
NSF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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