Article
Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism.
Neuron - 28 Apr 2011
Pang Zhiping P, Bacaj Taulant, Yang Xiaofei, Zhou Peng, Xu Wei, Südhof Thomas C
Abstract excerpt
Two families of Ca(2+)-binding proteins have been proposed as Ca(2+) sensors for spontaneous release: synaptotagmins and Doc2s, with the intriguing possibility that Doc2s may represent high-affinity Ca(2+) sensors that are activated by deletion of synaptotagmins, thereby accounting for the increased spontaneous release in synaptotagmin-deficient synapses. Here, we use an shRNA-dependent quadruple knockdown of all...
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