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Article

Calcium-dependent regulation of Rab activation and vesicle fusion by an intracellular P2X ion channel.

Nature cell biology - 1 Jan 2014

Parkinson Katie, Baines Abigail E, Keller Thomas, Gruenheit Nicole, Bragg Laricia, North R Alan, Thompson Christopher R L

Abstract excerpt

Rab GTPases play key roles in the delivery, docking and fusion of intracellular vesicles. However, the mechanism by which spatial and temporal regulation of Rab GTPase activity is controlled is poorly understood. Here we describe a mechanism by which localized calcium release through a vesicular ion channel controls Rab GTPase activity. We show that activation of P2XA, an intracellular ion channel localized to...

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Identifiers

PMID: 24335649
DOI: 10.1038/ncb2887
PMCID: PMC3942655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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