Article
Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2008
Bell Daphne W, Brannigan Brian W, Matsuo Keitaro, Finkelstein Dianne M, Sordella Raffaella, Settleman Jeff, Mitsudomi Tetsuya, Haber Daniel A
Abstract excerpt
PURPOSE: Somatic mutations in the epidermal growth factor receptor (EGFR) gene occur in a subset of non-small-cell lung cancer (NSCLC) and are highly predictive of the clinical response to selective EGFR kinase inhibitors. The prevalence of EGFR-mutant NSCLC is appreciably higher in females than in males and in East Asian than in Caucasian populations. We hypothesized that these disparate frequencies may be...
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