Article
Association of CYP19A1 polymorphisms with risks for atypical adenomatous hyperplasia and bronchioloalveolar carcinoma in the lungs.
Carcinogenesis - 1 Oct 2010
Kohno Takashi, Kakinuma Ryutaro, Iwasaki Motoki, Yamaji Taiki, Kunitoh Hideo, Suzuki Kenji, Shimada Yoko, Shiraishi Kouya, Kasuga Yoshio, Hamada Gerson Shigeaki, Furuta Koh, Tsuta Koji, Sakamoto Hiromi, Kuchiba Aya, Yamamoto Seiichiro, Kanai Yae, Tsugane Shoichiro, Yokota Jun
Abstract excerpt
Estrogen has been indicated to play an etiological role in the development of lung adenocarcinoma (ADC), particularly bronchioloalveolar carcinoma (BAC), a type of ADC that develops from a benign adenomatous lesion, atypical adenomatous hyperplasia (AAH). Polymorphisms in the CYP19A1 gene cause interindividual differences in estrogen levels. Here, 13 CYP19A1 single-nucleotide polymorphisms (SNPs) were examined...
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