EGFR L858R mutation and polymorphisms of genes related to estrogen biosynthesis and metabolism in never-smoking female lung adenocarcinoma patients.

doi:10.1158/1078-0432.CCR-10-2045

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Article

EGFR L858R mutation and polymorphisms of genes related to estrogen biosynthesis and metabolism in never-smoking female lung adenocarcinoma patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2011

Yang Shi-Yi, Yang Tsung-Ying, Chen Kun-Chieh, Li Yao-Jen, Hsu Kuo-Hsuan, Tsai Chi-Rne, Chen Chih-Yi, Hsu Chung-Ping, Hsia Jiun-Yi, Chuang Cheng-Yen, Tsai Ying-Huang, Chen Kuan-Yu, Huang Ming-Shyan, Su Wu-Chou, Chen Yuh-Min, Hsiung Chao A, Shen Chen-Yang, Chang Gee-Chen, Yang Pan-Chyr, Chen Chien-Jen

Abstract excerpt

PURPOSE: To assess whether polymorphisms of genes related to estrogen biosynthesis and metabolism are associated with EGFR mutations. EXPERIMENTAL DESIGN: We studied 617 patients with lung adenocarcinoma, including 302 never-smoking women. On the basis of multiple candidate genes approach, the effects of polymorphisms of CYP17, CYP19A1, ERα, and COMT in association with the occurrence of EGFR mutations were...

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PMID: 21300759
DOI: 10.1158/1078-0432.CCR-10-2045

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EGFR
COMT

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