Article
miR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells.
Hepatology (Baltimore, Md.) - 1 Sept 2013
Gailhouste Luc, Gomez-Santos Laura, Hagiwara Keitaro, Hatada Izuho, Kitagawa Noriyuki, Kawaharada Kazushi, Thirion Muriel, Kosaka Nobuyoshi, Takahashi Ryou-U, Shibata Tatsuhiro, Miyajima Atsushi, Ochiya Takahiro
Abstract excerpt
UNLABELLED: MicroRNAs (miRNAs) are evolutionary conserved small RNAs that post-transcriptionally regulate the expression of target genes. To date, the role of miRNAs in liver development is not fully understood. By using an experimental model that allows the induced and controlled differentiation of mouse fetal hepatoblasts (MFHs) into mature hepatocytes, we identified miR-148a as a hepatospecific miRNA highly...
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