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MiR-545-3p/MT1M axis regulates cell proliferation, invasion and migration in hepatocellular carcinoma

15 Sept 2018

Abstract excerpt

Studies have shown that metallothionein 1 M (MT1M) is a tumor suppressor gene which is frequently down-regulated in human hepatocellular carcinoma (HCC). The methylation of MT1M promoter region is one of the important transcriptional regulation mechanisms that contribute to the loss of its expression. In our study, we found that there are still half of the 55 HCC tumor tissues in our cohort do not share the...

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PMID: 30227328
DOI: 10.1016/j.biopha.2018.09.009

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