Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK.

doi:10.1200/JCO.2009.22.6993

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Article

Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Sept 2009

Shaw Alice T, Yeap Beow Y, Mino-Kenudson Mari, Digumarthy Subba R, Costa Daniel B, Heist Rebecca S, Solomon Benjamin, Stubbs Hannah, Admane Sonal, McDermott Ultan, Settleman Jeffrey, Kobayashi Susumu, Mark Eugene J, Rodig Scott J, Chirieac Lucian R, Kwak Eunice L, Lynch Thomas J, Iafrate A John

Abstract excerpt

PURPOSE: The EML4-ALK fusion oncogene represents a novel molecular target in a small subset of non-small-cell lung cancers (NSCLC). To aid in identification and treatment of these patients, we examined the clinical characteristics and treatment outcomes of patients who had NSCLC with and without EML4-ALK. PATIENTS AND METHODS: Patients with NSCLC were selected for genetic screening on the basis of two or more of...

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Identifiers

PMID: 19667264
DOI: 10.1200/JCO.2009.22.6993
PMCID: PMC2744268

Genes

ALK
EML4
EGFR
KRAS

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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