Article
Mitochondrial haplogroup H1 is protective for ischemic stroke in Portuguese patients.
BMC medical genetics - 1 Jul 2008
Rosa Alexandra, Fonseca Benedita V, Krug Tiago, Manso Helena, Gouveia Liliana, Albergaria Isabel, Gaspar Gisela, Correia Manuel, Viana-Baptista Miguel, Simões Rita Moiron, Pinto Amélia Nogueira, Taipa Ricardo, Ferreira Carla, Fontes João Ramalho, Silva Mário Rui, Gabriel João Paulo, Matos Ilda, Lopes Gabriela, Ferro José M, Vicente Astrid M, Oliveira Sofia A
Abstract excerpt
BACKGROUND: The genetic contribution to stroke is well established but it has proven difficult to identify the genes and the disease-associated alleles mediating this effect, possibly because only nuclear genes have been intensely investigated so far. Mitochondrial DNA (mtDNA) has been implicated in several disorders having stroke as one of its clinical manifestations. The aim of this case-control study was to...
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