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The loss of antibody productivity in continuous culture of hybridoma cells

5 Mar 1990

Abstract excerpt

Two hybridoma lines, HB8178 and AFP-27, were grown in continuous culture. The concentrations of viable cells as well as those of various nutrients and metabolites reached steady-state values. The concentrations of either total IgG or antigen-specific antibody, however, failed to reach steady-state values but rather continuously decreased over the course of the cultures. The fraction of antibody-producing cells in...

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PMID: 18592539
DOI: 10.1002/bit.260350504

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