Enhanced Antibody Production at Slowed Growth Rates: Experimental Demonstration and a Simple Structured Model

Abstract excerpt

A simple structured model for monoclonal antibody (MAb) production kinetics was formulated by combining the cell cycle theory with the estimated number of MAb-coded messenger RNA (mRNA) molecules per cell: it is assumed that the rate-controlling step is first order in this mRNA and that the growth rate variation does not alter the MAb synthesis rate within any cycle phase but only changes the relative time length...

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