Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2008

Adeeku Eric, Gudapati Prathyusha, Mendez-Fernandez Yanice, Van Kaer Luc, Boothby Mark

Abstract excerpt

Differentiation of T helper (Th) subset 2 effector lymphocytes is thought to foreclose on IFN-gamma gene expression. Using an IL-4 locus modified to detect transcriptional induction of this effector cytokine gene in developing Th2 cells, we show here that these cells contributed effectively to a long-term memory population. A memory CD4 subset formed efficiently from an activated population after transcriptional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adoptive Transfer
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Lineage

Share to Immunologic Memory

Share to Interferon-gamma

Share to Interleukin-4

Share to T-Lymphocyte Subsets

Share to Th2 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 18591677
DOI: 10.1073/pnas.0704807105
PMCID: PMC2453725

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors.PMID 18591677Read ↗

Rapid Recall Ability of Memory T cells is Encoded in their EpigenomeSemantic proximity Read ↗

Stability and commitment in T helper cell development.Semantic proximity Read ↗

Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.Semantic proximity Read ↗

Memory T cell rapid recall is driven by memory-specific AP-1 recruitment determined by epigenome and co-factor interactionsSemantic proximity Read ↗

Stochastic Episodes of Latent Cytomegalovirus Transcription Drive CD8 T-Cell "Memory Inflation" and Avoid Immune Evasion.Semantic proximity Read ↗

Early Th1/Th2 cell polarization in the absence of IL-4 and IL-12: T cell receptor signaling regulates the response to cytokines in CD4 and CD8 T cells.Semantic proximity Read ↗

GATA-3 transcriptional imprinting in Th2 lymphocytes: A mathematical modelSemantic proximity Read ↗

STAT6 tunes maximum T cell IL-4 production from stochastically regulated Il4 alleles.Semantic proximity Read ↗

TCR independent suppression of CD8(+) T cell cytokine production mediated by IFNγ in vivo.Semantic proximity Read ↗

IFNγ-induced memory in human macrophages is not sustained by epigenetic changes but the durability of the cytokine itselfSemantic proximity Read ↗

In differentiated CD4+ T cells, interleukin 4 production is cytokine-autonomous, whereas interferon gamma production is cytokine-dependent.Semantic proximity Read ↗

Recall helper T cell response: T helper 1 cell-resistant allergic susceptibility without biasing uncommitted CD4 T cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.