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Article

GATA-3 transcriptional imprinting in Th2 lymphocytes: A mathematical model

26 Jun 2002

Abstract excerpt

Immunological memory involves the fast recall of cytokine expression by T helper (Th) lymphocytes. Two distinct profiles of cytokine expression, Th1 and Th2, can be induced by antigen and polarizing signals during activation of naive Th cells and can subsequently be reexpressed on stimulation by antigen alone. The transcription factor GATA-3 induces Th2 development. GATA-3 is activated by the Th2-polarizing...

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PMID: 12087127
DOI: 10.1073/pnas.142284699

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